Berberine
Berberine
60 Capsules 500mg
Berberine LEO-HB® is an extra-bioavailable form of berberine, thanks to its water-solubility. Packed with antioxidants, this formula is designed to boost your metabolic health, gut wellness, and healthy cholesterol – while helping to keep your blood sugar in balance.
Berberine LEO-HB® is a trademark of ELEONOR SPRL, Belgium.
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How to Use
How to Use
As a dietary supplement, take 1 capsule, 1-2 times daily, with or between meals.
Health Benefits
Health Benefits
- Water Soluble & Bioavailable*
- PromotesGut Health*
- Metabolic Health*
- Heart health*
- Antioxidant*
- Cholesterol Support*
Ingredients/Nutritional Information
Ingredients/Nutritional Information
| Amount per serving | % DV |
|
|---|---|---|
| Berberine LEO-HB® : (Berberis aristata) Extract (root) (min 30% Berberine Hcl) | 500mg | ** |
Other ingredients: Hydrolyzed Collagen, Rice Fiber, Hypromellose Capsule, Glycerin.
Science & Research
Science & Research
- https://leohb.com/ingredients/introducing-berberine-leo-hb/
- Efficacy of Berberine in Patients with Type 2 Diabetes- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410097/
- Berberine Lowers Blood Glucose in Type 2 Diabetes Mellitus Patients through Increasing Insulin Receptor Expression – Metabolism (2010) https://pubmed.ncbi.nlm.nih.gov/19800084/
- Glucose-lowering effect of berberine on type 2 diabetes: A systematic review and meta-analysis Frontiers in Pharmacology (2022) https://www.frontiersin.org/articles/10.3389/fphar.2022.1015045/full
- Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease – PLOS One (2015) https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134172
- Efficacy of Berberine Alone and in Combination for the Treatment of Hyperlipidemia: A Systematic Review, J. Evidence-based Compl. & Alt Medicine, 2017 https://pubmed.ncbi.nlm.nih.gov/29228784/
- Berberine on the Prevention and Management of Cardiometabolic Disease: Clinical Applications and Mechanisms of Action – Amer Journal of Chinese Medicine (2021) https://pubmed.ncbi.nlm.nih.gov/34488551/
- On the mechanism of antidepressant-like action of berberine chloride European Journal of Pharmacology (2008) https://www.sciencedirect.com/science/article/abs/pii/S0014299908005694?via%3Dihub
Berberine but better.
If you’re looking for berberine, you already know what it’s all about. The difference with ours is that it’s water-soluble to boost bioavailability. That means the benefits are more pronounced, and you feel them faster.
The antioxidant-rich formula and food-grade ingredients are a nice bonus.
- Non-GMO
- Emulsifier & Solvent Free
- Gluten Free
Tested. Inspected. Perfected.
Our products are exceptional. But obviously we’re a little biased. Which is why we work with third-party labs to make sure everything we sell is pure, fresh, and does the job it says it will.
Just take your product’s lot number (that’s the code next to the expiration date) and enter it here. You’ll get a full rundown of how it was tested, and how it performed against pharmaceutical standards. It’s like a report card for your supplements, and we don’t put anything in front of you unless it passes with flying colours.
Check out an example Lab Report of this product here.
FAQs
Can we make Berberine more effective?
Berberine has been used for millennia in traditional Chinese and Ayurvedic medicine to treat infections, digestive issues, and other conditions, and has recently surged in popularity due to social media buzz—being dubbed 'nature’s Ozempic' and growing interest in its gut, metabolic, and weight-related benefits.
Berberine’s primary actions occur in the intestine: conversion by gut microbiota in the intestine, local intestinal effects. But due to its poor oral bioavailability, various enhanced absorption technologies exist—such as phytosomes, liposomes, and others. (Fratter, A. & De Servi, B. (2014). Int. J. Drug Deliv. Technol. 5, 33–42.)
Berberine LEO-HB is designed to enhance the interaction between berberine, gut
tissues, and the microbiota.
Why does solubility matter for Berberine?
Berberine’s enhanced solubility improves its interaction with:
- Gut hormones related to satiety (e.g., ghrelin, PYY)
- Enzymes involved in sugar and fat assimilation (e.g., glycosylase, amylase, lipases)
- Microbiota that support gut health and influence metabolic processes
This can contribute to improved absorption and greater overall effectiveness.
What is LEO-HB?
You’ve probably heard of liposomes and phytosomes, but despite being founded back in 2007, the Belgian company Eleonor’s LEO-HB technology only began gaining broader recognition in the 2020s. Their approach is different: by combining a food matrix with micro-dispersion technology, LEO-HB helps transform poorly soluble substances into high-performance actives.
How does LEO-HB technology work?
LEO-HB technology does not encapsulate Berberine into liposomes or other spherosomes. Instead, it aims to enhance the interaction between Berberine, gut tissues, and the microbiota by micro-dispersing Berberine HCl into a compatible, soluble food matrix. This process transforms berberine from its crystalline form into an amorphous form by incorporating soluble matrix molecules between the non-soluble bioactive molecules, resulting in improved water dispersibility and solubility—regardless of varying pH levels in the gastrointestinal system.
What’s Food Matrix?
LEO-HB Berberine is formulated with food grade ingredients: collagen peptides, glycerol, and the active ingredient – Berberine HCl. Free from solvents and emulsifiers. It's also gluten free and non-GMO. Collagen peptides serve as the food matrix.
How and when to take SO Berberine?
Unlike regular berberine HCl, SO Berberine works in any pH (stomach pH is more acidic before meals, less acidic after), so there’s no need to take it at a specific time.
Take 1 capsule once or twice daily.
SO Berberine LEO-HB vs Berberine Phytosome/Liposome?
All of these technologies have one thing in common: they enhance berberine’s solubility and oral bioavailability. However, LEO-HB doesn’t use any solvents, while technologies like phytosome & liposome involve organic solvents and evaporation.
My dr. suggested I try berberine before starting metformin. It did help, but I had to take it with plenty of food or limit the dose to 200 mg, higher doses upset my stomach. No issues with this one, even if I take it on an empty stomach. I’d recommend it if you can’t tolerate regular Berberine.As a side note, I appreciate that I can access the third-party lab report directly on their website (science-only.com)
Mainly trying this out for gut and metabolic health so it's too early to say that it's working. I do like the packaging and the pills are easy to swallow without any bad tastes.
First of all, I really respect that Science Only provides third party lab test results, and has them readily available on their site. Kudos to that.LEO-HB is a new technology for increasing the absorption/bioavailability of compounds that normally have poor absorption. Berberine is such a compound that has poor bioavailability when taken in it's native form. Liposome/phytosomes technology has been used over the past few years to also increase the bioavailability of Berberine, but LEO-HB claims to be better than liposomes.LEO-HB does not encapsulate bioactives into liposomes or other spherosomes. Instead, its goal is to enhance the interaction between selected bioactives, gut tissues, and the microbiota. The first step of the process is to choose a compatible water-soluble food matrix (base). Next, the bioactive compound (Berberine HCl) is loaded into the food matrix. LEO-HB micro-disperses the selected bioactives into the compatible soluble food matrix. This process transitions the bioactives from a crystalline form to an amorphous form — essentially incorporating soluble matrix molecules between the non-soluble bioactive molecules.In the case of Berberine, this enhanced solubility improves its interaction with:Digestive enzymes responsible for satiety (e.g., ghrelin, PYY)Enzymes involved in sugar and fat assimilation (e.g., glycosylase, amylase, lipases)Microbiota that support gut health and influence metabolic processesThis ultimately leads to better Berberine absorption.LEO-HB vs Phytosomes/Liposomes/Cyclodextrins:All of these technologies have one thing in common: they enhance Berberine’s solubility and oral bioavailability, but LEO-HB doesn't use any kinds of solvents (Phytosomes use organic solvents + evaporation).
SO Science Only's Berberine Leo-HB arrived well sealed.This is supposedly a better absorbing berberine and that is what led me to order this.The medium sized capsules are all intact with no residual powder inside and they are easy to swallow at recommended one per day.The bottle mentions that it is made in USA with globally sourced ingredients but no mention if that facility is cGMP.There is a manufactured date of 2/2025 stamped on the bottom.
My doctor recommended Berberine to manage my cholesterol, and I've had good success with it. This product hasn't give me any unwanted side effects or negative issues.I'm not sure about the brand, however. I typically take a look at all the products made by supplement companies before I buy into a brand. SO only has 2 products for sale, so I'm not totally comfortable with them. However, you can find Leo-HB with a quick internet search, which is why I've rated this higher than I normally would.